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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
30.3
Human Site:
S103
Identified Species:
41.67
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
S103
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
S103
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
S103
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Dog
Lupus familis
XP_547091
832
93293
S331
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
S103
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Rat
Rattus norvegicus
Q62673
603
68295
S103
E
K
M
S
M
E
T
S
I
H
R
S
L
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
Y33
V
T
E
P
E
A
R
Y
Y
L
R
Q
I
I
L
Chicken
Gallus gallus
NP_001025810
595
66904
A93
E
K
M
S
M
E
I
A
I
H
R
S
L
A
H
Frog
Xenopus laevis
P70032
598
68193
A94
D
K
M
T
M
E
I
A
I
Q
R
S
L
D
H
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
A89
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
T75
E
K
T
A
Q
E
I
T
I
H
R
S
L
N
H
Honey Bee
Apis mellifera
XP_396707
575
66141
S73
E
K
M
T
Q
E
I
S
I
H
Q
T
L
N
H
Nematode Worm
Caenorhab. elegans
P34331
649
73615
I88
D
K
V
D
N
E
R
I
L
I
H
R
E
L
G
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
H77
D
K
M
T
M
E
I
H
I
H
K
S
L
H
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
K86
Q
K
L
I
S
E
I
K
I
H
K
S
L
R
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
Q131
K
K
L
L
S
E
I
Q
I
H
K
S
M
S
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
100
N.A.
100
86.6
N.A.
6.6
93.3
66.6
66.6
N.A.
66.6
66.6
13.3
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
13.3
100
86.6
86.6
N.A.
80
86.6
33.3
86.6
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
53.3
N.A.
0
46.6
N.A.
P-Site Similarity:
N.A.
73.3
N.A.
0
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
0
6
0
18
0
0
0
0
0
36
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
18
0
0
6
0
0
0
0
0
0
0
0
0
12
0
% D
% Glu:
59
0
6
0
6
89
0
0
0
0
0
0
6
6
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6
% G
% His:
0
0
0
0
0
0
0
6
0
77
6
0
0
6
77
% H
% Ile:
0
0
0
6
0
0
77
6
83
6
0
0
6
6
0
% I
% Lys:
6
89
0
0
0
0
0
6
0
0
24
0
0
0
0
% K
% Leu:
0
0
12
6
0
0
0
0
6
6
0
0
77
6
6
% L
% Met:
0
0
65
0
53
0
0
0
0
0
0
0
6
0
0
% M
% Asn:
0
0
0
0
6
0
0
0
0
0
0
0
0
12
6
% N
% Pro:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
6
0
0
0
12
0
0
6
0
6
6
6
0
0
0
% Q
% Arg:
0
0
0
0
0
0
12
0
0
0
59
6
0
6
0
% R
% Ser:
0
0
0
48
12
0
0
42
0
0
0
77
0
6
0
% S
% Thr:
0
6
6
18
6
0
6
6
0
0
0
6
0
0
0
% T
% Val:
6
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
6
6
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _